Argireline Solution 10%
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Argireline Solution 10%

Argireline Solution 10%

A lightweight, water-based peptide serum featuring 10% Argireline (Acetyl Hexapeptide-8) that targets expression lines around the forehead, eyes, and smile area. Often called "Botox in a bottle," this non-injective formula helps relax the appearance of dynamic wrinkles for smoother, more youthful-looking skin.

๐Ÿ‡จ๐Ÿ‡ฆ Clean Beauty ยท Made in Canada
โœ” Vegan โœ” Cruelty-Free โœ” Fragrance-Free โœ” Oil-Free โœ” Silicone-Free โœ” Alcohol-Free โœ” Gluten-Free โœ” Fungal Acne Safe
Pregnancy Safe
Caution โš ๏ธ
Fungal Acne Safe
Yes โœ”
Comedogenic Rating
0/5
๐Ÿ’ง
Size
30ml / 1 fl oz
๐Ÿงช
Active
10% Argireline
๐Ÿ“Š
pH Level
~6.0
๐ŸŽฏ
Target
Expression Lines
โฐ
Use
AM & PM

โœจ Texture & Feel

๐Ÿ’ง
Consistency
Watery Serum
๐Ÿ‘ƒ
Scent
Fragrance-Free
โฑ๏ธ
Absorption
Instant
๐ŸŽฏ
Finish
Natural/Hydrated
๐Ÿ’‰

Non-Injective Anti-Aging

Mimics the muscle-relaxing effects of Botox topically without needles, helping to soften dynamic expression lines.

๐ŸŽฏ

Targeted Treatment

Specifically formulated for forehead lines, "eleven" frown lines, crow's feet, and smile lines.

๐Ÿ’ง

Water-Based Formula

High water content maximizes Argireline efficacy. Free from oils, esters, and silicones for better absorption.

๐Ÿงด

Minimalist Formulation

Only 11 ingredients focused on delivering the active without unnecessary fillers or irritants.

๐Ÿ›ก๏ธ Safety & Compatibility

โš ๏ธ
Pregnancy & Breastfeeding

Limited data available. No studies have identified harmful effects, but consult your healthcare provider before use as a precaution.

โœ…
Fungal Acne (Malassezia) Safe

Contains no fatty acids, oils, esters, polysorbates, or fermented ingredients that feed malassezia yeast.

โœ…
Non-Comedogenic

Rating 0/5. Oil-free and silicone-free formula will not clog pores or cause breakouts.

โœ…
Sensitive Skin Friendly

Fragrance-free, alcohol-free formula with low irritation potential. Patch test recommended for very reactive skin.

โš ๏ธ
Avoid with Direct Acids & Vitamin C

Do not use in the same routine as AHAs, BHAs, L-Ascorbic Acid, or Ethylated Vitamin C. Low pH can reduce peptide efficacy.

๐Ÿ’ก
Patch Test Recommended

Apply a small amount to inner forearm and wait 24 hours before full facial application.

๐Ÿ”ฌ Ingredient Breakdown

๐Ÿงฌ Argireline (Acetyl Hexapeptide-8) 10% Proven

A synthetic hexapeptide that works by inhibiting the SNARE complex, reducing neurotransmitter release that causes muscle contractions. This relaxes facial muscles and reduces the appearance of expression lines.

  • Clinical Study: 10% Argireline reduced wrinkle depth by 17% after 15 days of use around the eyes.
  • Research: 5% concentration showed 16.26% decrease in wrinkle depth after 28 days.
  • Mechanism: Mimics SNAP-25 protein fragment, similar to botulinum toxin's target but applied topically.
  • NIH Study: Can extend Botox results when used regularly between treatments.
โš ๏ธ
Works best with consistent twice-daily use. Results are gradual and not as dramatic as injectable Botox.

๐Ÿ’ง Propanediol Solvent Supporting

A naturally-derived solvent (from corn) that enhances the absorption and penetration of Argireline into the skin. Also provides light hydration and improves product texture.

  • Function: Enhances delivery of active ingredients into skin
  • Source: Plant-derived, sustainable alternative to propylene glycol
  • Benefit: Moisturizing properties without heaviness

๐Ÿ”— Dimethyl Isosorbide Penetration Enhancer Supporting

A penetration enhancer that helps active ingredients reach deeper skin layers where they can be most effective. Improves the bioavailability of Argireline.

  • Function: Boosts delivery of peptides through the skin barrier
  • Safety: Well-tolerated, non-irritating carrier ingredient

11 ingredients

Aqua (Water), Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin

FREE FROM: Parabens, Sulfates (SLS/SLES), Mineral Oil, Silicones, Oils, Fragrance, Alcohol, Gluten, Animal-derived Ingredients, Formaldehyde, Phthalates, Oxybenzone, Coal Tar, Hydroquinone, Triclosan

๐Ÿ”„ Where It Fits in Your Routine

1
Cleanser
2
Toner
3
Argireline Serum
4
Hydrating Serum
5
Moisturizer
6
Sunscreen (AM)

Apply in the "Treat" stage after cleansing/toning and before heavier treatments. Water-based serums go before oil-based products.

๐Ÿ“ How to Use

1

Cleanse & Prep

Start with clean, dry skin. Use after toner if applicable. Skin should be free of makeup and debris.

2

Apply to Target Areas

Dispense a few drops onto fingertips. Apply directly to forehead lines, between eyebrows (eleven lines), crow's feet, and smile lines.

3

Gently Pat In

Use gentle patting motions to help absorption. Avoid rubbing or pulling at the delicate eye area. Allow to absorb for 1-2 minutes.

4

Follow with Moisturizer

Layer with a moisturizer to seal in hydration. As a humectant, Argireline works best when followed by an occlusive product.

5

Use Twice Daily

Apply morning and evening for best results. Consistency is key โ€“ allow 4-8 weeks for visible improvement.

๐Ÿ‘ค Who Is It For?

โœ… Perfect for you if:

  • You have visible expression lines (forehead, crow's feet, frown lines)
  • You want a non-invasive alternative to Botox
  • You're looking for preventative anti-aging in your 20s-30s
  • You prefer clean, minimalist formulations
  • You have sensitive or acne-prone skin
  • You want to extend time between Botox appointments
  • You're on a budget but want effective anti-aging

โŒ Consider alternatives if:

  • You expect Botox-level results (this is gentler)
  • You have deep, static wrinkles (better for dynamic lines)
  • You're impatient โ€“ results take 4-8 weeks
  • You want an all-in-one anti-aging serum
  • You use a lot of direct acids or L-Ascorbic Acid Vitamin C
  • You're pregnant/breastfeeding (consult doctor first)

๐ŸŽฏ Skin Type Compatibility

Oily Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Lightweight, oil-free formula absorbs instantly without adding shine or greasiness. Won't clog pores.

Dry Skin โ˜…โ˜…โ˜…โ˜…โ˜† Good

Provides light hydration but will need a richer moisturizer on top. The humectant properties help attract moisture.

Combination Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Balanced formula works well across different face zones. Light enough for T-zone, hydrating for dry areas.

Sensitive Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Fragrance-free, alcohol-free, minimal ingredients. Low irritation potential. Patch test for very reactive skin.

Acne-Prone Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Non-comedogenic (0/5), oil-free, fungal acne safe. Won't trigger breakouts or feed acne-causing bacteria/yeast.

Mature Skin โ˜…โ˜…โ˜…โ˜…โ˜† Good

Best for dynamic wrinkles. For deep static wrinkles, combine with retinol (separate routines) or collagen-boosting treatments.

๐Ÿ“ˆ Results Timeline

Week 1-2

Initial Hydration & Smoothing

Skin feels more hydrated and slightly smoother. Temporary tightening sensation upon application. Product integrates into routine.

85% notice improved skin texture
Week 2-4

Early Wrinkle Softening

Fine lines begin to appear softer, especially around the eyes. Dynamic wrinkles look less pronounced when face is relaxed. Skin appears plumper.

65% see visible line reduction
Week 4-8

Noticeable Results

Clinical studies show 16-17% reduction in wrinkle depth. Expression lines on forehead and crow's feet visibly improved. Skin looks more relaxed and youthful.

64% report significant improvement
Month 3+

Cumulative Benefits

Continued use maintains results and may provide additional improvement. Preventative benefits for future wrinkle formation. Best results with consistent daily use.

Maintenance phase โ€“ ongoing use recommended

โญ Ratings by Platform

๐Ÿ’„ Sephora
โ˜…โ˜…โ˜…โ˜… 4.0
Rating
400+
Reviews
โš ๏ธ Main complaint: Results take time and are subtle compared to Botox expectations
๐Ÿ’… Ulta
โ˜…โ˜…โ˜…โ˜… 4.1
Rating
250+
Reviews
โš ๏ธ Main complaint: Small bottle size, requires consistent daily use
๐Ÿ›’ Amazon
โ˜…โ˜…โ˜…โ˜… 4.3
Rating
4,000+
Reviews
โš ๏ธ Main complaint: Concerns about product authenticity from third-party sellers
๐Ÿ  The Ordinary Website
โ˜…โ˜…โ˜…โ˜… 3.9
Rating
2,000+
Reviews
โš ๏ธ Main complaint: Some find the 6-month PAO limiting

โš–๏ธ Pros & Cons

โœ… Praised

  • Exceptional value โ€“ clinical peptide at drugstore price (~$10)
  • Lightweight, fast-absorbing, no residue
  • Suitable for all skin types including sensitive
  • Clean, minimal ingredient list (only 11 ingredients)
  • Fungal acne and acne-safe formula
  • Noticeable softening of expression lines with consistent use
  • Can extend Botox results between appointments
  • Fragrance-free, doesn't irritate eyes
  • Layers well under other products and makeup

โŒ Criticized

  • Results are gradual โ€“ not instant like Botox
  • Doesn't work as well on deep, static wrinkles
  • 6-month shelf life after opening is short
  • Small 30ml bottle can run out quickly with 2x daily use
  • Can pill under some products if not fully absorbed
  • Cannot use with direct acids or L-Ascorbic Acid
  • Some users see no visible difference
  • Requires patience and consistency

๐Ÿ’ฐ Budget-Friendly Alternatives (Dupes)

90% Match
Inzora Argi Matrix Serum (10% Argireline + 5% Matrixyl)
$8.99 Budget Pick

Combines Argireline with Matrixyl 3000 and Hyaluronic Acid in one formula. Slightly more complex but offers collagen-boosting benefits too.

85% Match
Cos De BAHA Peptide Serum with Matrixyl 3000 & Argireline
$14.80 Similar Price

Larger 60ml bottle with both peptides plus chamomile extract for soothing. More hydrating formula but less concentrated Argireline.

75% Match
ASTERWOOD Naturals Matrixyl 3000 + Argireline Serum
$19.95 Similar Price

Professional-grade peptide serum with organic Hyaluronic Acid. Larger 1oz size. Focus on both muscle relaxation and collagen synthesis.

70% Match
The Ordinary Multi-Peptide + HA Serum (Buffet)
$19.90 Premium Option

Contains Argireline plus Matrixyl and other peptides. Multi-target approach for overall anti-aging vs. focused expression line treatment.

๐Ÿ”„ Comparison with Competitors

The Ordinary Matrixyl 10% + HA

$16.20
Key Active 10% Matrixyl 3000
Size 30ml
Target Collagen/Firmness
Additional Benefits + Hyaluronic Acid
Price/ml $0.54/ml

The Ordinary Multi-Peptide + HA Serum

$19.90
Key Active Multiple Peptides
Size 30ml
Target Overall Anti-Aging
Additional Benefits Argireline + Matrixyl + More
Price/ml $0.66/ml

Peter Thomas Roth Peptide 21 Serum

$110.00
Key Active 21 Peptides + Neuropeptides
Size 30ml
Target Premium Anti-Aging
Additional Benefits Complex blend
Price/ml $3.67/ml

๐Ÿ“ฆ Storage & Shelf Life

๐Ÿ“…
Period After Opening (PAO)

6 months after opening. Mark the opening date on your bottle.

๐Ÿ 
Storage

Store in a cool, dry place away from direct sunlight. Refrigeration is optional but can extend freshness.

๐Ÿ“ฆ
Packaging

Glass dropper bottle with pipette applicator for precise dispensing and hygienic application.

โœˆ๏ธ
Travel Friendly

Yes, 30ml is under the 100ml TSA liquid limit. Pack upright to prevent leakage.

โ“ Frequently Asked Questions

There is limited data available. No studies have identified harmful effects from topical Argireline during pregnancy or breastfeeding. However, DECIEM has not conducted specific testing on pregnant or breastfeeding individuals. As a precaution, consult your healthcare provider or dermatologist before use. Many experts consider peptides generally safer than retinoids, but it's best to get professional guidance for your specific situation.

Yes! This product is completely fungal acne safe. It contains no fatty acids, oils, esters, polysorbates, or fermented ingredients that feed malassezia yeast. The water-based formula is free from all known triggers. Multiple sources including Skincarisma and SkinSort confirm its FA-safe status.

With retinol: Yes, you can use them together. Apply Argireline first as it's water-based, then retinol. Or use Argireline AM and retinol PM. With Vitamin C: Avoid using with L-Ascorbic Acid (direct vitamin C) in the same routine as the low pH can reduce peptide effectiveness. Stable vitamin C derivatives like Ascorbyl Tetraisopalmitate are fine. With AHA/BHA: Do not use in the same routine. Direct acids can degrade peptides. Use them at different times of day or on alternate days.

This serum is suitable for ALL skin types, including sensitive, oily, dry, combination, acne-prone, and mature skin. The lightweight, oil-free formula works especially well for oily and acne-prone skin. Those with dry skin should follow with a hydrating moisturizer. The fragrance-free, minimal formula makes it excellent for sensitive skin.

Initial hydration and smoothing: 1-2 weeks. Visible softening of fine lines: 2-4 weeks. Clinical studies show 16-17% reduction in wrinkle depth after 15-28 days of consistent use. Most users report noticeable results at the 4-8 week mark. Results accumulate with continued use. This is not an instant fix like Botox โ€“ patience and consistency are required.

Apply in the "Treat" step: After cleansing and toning, before heavier serums, oils, and moisturizers. As a water-based serum, it should go before any oil-based products. The order is: Cleanser โ†’ Toner โ†’ Argireline โ†’ Other serums โ†’ Moisturizer โ†’ Sunscreen (AM). Use morning and evening for best results.

No, this product has a comedogenic rating of 0/5. It is completely non-comedogenic. The oil-free, silicone-free formula contains no pore-clogging ingredients. It's safe for acne-prone skin and those who struggle with clogged pores or blackheads.

The Period After Opening (PAO) is 6 months. Once opened, peptides can degrade over time, so it's important to use the product within this timeframe. With twice-daily use on target areas, the 30ml bottle typically lasts 2-4 months, well within the PAO. Store properly in a cool, dry place away from sunlight to maximize shelf life.

Yes, you can apply it all over your face and neck if desired, though it's designed primarily for expression line areas (forehead, between brows, crow's feet, smile lines). Many users find it hydrating for the entire face. The gentle formula is safe for widespread use.

While Argireline works through a similar mechanism to Botox (inhibiting muscle contractions), it's important to have realistic expectations. It's NOT as powerful as injectable Botox. Clinical studies show it can reduce wrinkle depth by about 17% โ€“ impressive for a topical, but nowhere near Botox results. Think of it as a gentle, non-invasive alternative for fine lines, or as a complement to extend time between Botox appointments. It's best for prevention and mild improvement rather than dramatic transformation.

โ˜…โ˜…โ˜…โ˜…โ˜†
4.0 out of 5

Verdict: The Ordinary Argireline Solution 10% delivers exceptional value as a targeted treatment for expression lines. At under $10 for a clinical-grade peptide serum, it's hard to beat. While it won't replace Botox, consistent users report visibly softer forehead lines and crow's feet within 4-8 weeks. The clean, minimalist formula suits all skin types including sensitive and acne-prone skin. Best for those seeking preventative anti-aging or gentle wrinkle softening. Requires patience and consistency โ€“ this is a marathon, not a sprint. Ideal as part of a comprehensive anti-aging routine alongside sunscreen and retinol (used separately).

$96,014,997.90
Argireline Solution 10%โ€”
$96,014,997.90

Argireline Solution 10%

A lightweight, water-based peptide serum featuring 10% Argireline (Acetyl Hexapeptide-8) that targets expression lines around the forehead, eyes, and smile area. Often called "Botox in a bottle," this non-injective formula helps relax the appearance of dynamic wrinkles for smoother, more youthful-looking skin.

๐Ÿ‡จ๐Ÿ‡ฆ Clean Beauty ยท Made in Canada
โœ” Vegan โœ” Cruelty-Free โœ” Fragrance-Free โœ” Oil-Free โœ” Silicone-Free โœ” Alcohol-Free โœ” Gluten-Free โœ” Fungal Acne Safe
Pregnancy Safe
Caution โš ๏ธ
Fungal Acne Safe
Yes โœ”
Comedogenic Rating
0/5
๐Ÿ’ง
Size
30ml / 1 fl oz
๐Ÿงช
Active
10% Argireline
๐Ÿ“Š
pH Level
~6.0
๐ŸŽฏ
Target
Expression Lines
โฐ
Use
AM & PM

โœจ Texture & Feel

๐Ÿ’ง
Consistency
Watery Serum
๐Ÿ‘ƒ
Scent
Fragrance-Free
โฑ๏ธ
Absorption
Instant
๐ŸŽฏ
Finish
Natural/Hydrated
๐Ÿ’‰

Non-Injective Anti-Aging

Mimics the muscle-relaxing effects of Botox topically without needles, helping to soften dynamic expression lines.

๐ŸŽฏ

Targeted Treatment

Specifically formulated for forehead lines, "eleven" frown lines, crow's feet, and smile lines.

๐Ÿ’ง

Water-Based Formula

High water content maximizes Argireline efficacy. Free from oils, esters, and silicones for better absorption.

๐Ÿงด

Minimalist Formulation

Only 11 ingredients focused on delivering the active without unnecessary fillers or irritants.

๐Ÿ›ก๏ธ Safety & Compatibility

โš ๏ธ
Pregnancy & Breastfeeding

Limited data available. No studies have identified harmful effects, but consult your healthcare provider before use as a precaution.

โœ…
Fungal Acne (Malassezia) Safe

Contains no fatty acids, oils, esters, polysorbates, or fermented ingredients that feed malassezia yeast.

โœ…
Non-Comedogenic

Rating 0/5. Oil-free and silicone-free formula will not clog pores or cause breakouts.

โœ…
Sensitive Skin Friendly

Fragrance-free, alcohol-free formula with low irritation potential. Patch test recommended for very reactive skin.

โš ๏ธ
Avoid with Direct Acids & Vitamin C

Do not use in the same routine as AHAs, BHAs, L-Ascorbic Acid, or Ethylated Vitamin C. Low pH can reduce peptide efficacy.

๐Ÿ’ก
Patch Test Recommended

Apply a small amount to inner forearm and wait 24 hours before full facial application.

๐Ÿ”ฌ Ingredient Breakdown

๐Ÿงฌ Argireline (Acetyl Hexapeptide-8) 10% Proven

A synthetic hexapeptide that works by inhibiting the SNARE complex, reducing neurotransmitter release that causes muscle contractions. This relaxes facial muscles and reduces the appearance of expression lines.

  • Clinical Study: 10% Argireline reduced wrinkle depth by 17% after 15 days of use around the eyes.
  • Research: 5% concentration showed 16.26% decrease in wrinkle depth after 28 days.
  • Mechanism: Mimics SNAP-25 protein fragment, similar to botulinum toxin's target but applied topically.
  • NIH Study: Can extend Botox results when used regularly between treatments.
โš ๏ธ
Works best with consistent twice-daily use. Results are gradual and not as dramatic as injectable Botox.

๐Ÿ’ง Propanediol Solvent Supporting

A naturally-derived solvent (from corn) that enhances the absorption and penetration of Argireline into the skin. Also provides light hydration and improves product texture.

  • Function: Enhances delivery of active ingredients into skin
  • Source: Plant-derived, sustainable alternative to propylene glycol
  • Benefit: Moisturizing properties without heaviness

๐Ÿ”— Dimethyl Isosorbide Penetration Enhancer Supporting

A penetration enhancer that helps active ingredients reach deeper skin layers where they can be most effective. Improves the bioavailability of Argireline.

  • Function: Boosts delivery of peptides through the skin barrier
  • Safety: Well-tolerated, non-irritating carrier ingredient

11 ingredients

Aqua (Water), Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin

FREE FROM: Parabens, Sulfates (SLS/SLES), Mineral Oil, Silicones, Oils, Fragrance, Alcohol, Gluten, Animal-derived Ingredients, Formaldehyde, Phthalates, Oxybenzone, Coal Tar, Hydroquinone, Triclosan

๐Ÿ”„ Where It Fits in Your Routine

1
Cleanser
2
Toner
3
Argireline Serum
4
Hydrating Serum
5
Moisturizer
6
Sunscreen (AM)

Apply in the "Treat" stage after cleansing/toning and before heavier treatments. Water-based serums go before oil-based products.

๐Ÿ“ How to Use

1

Cleanse & Prep

Start with clean, dry skin. Use after toner if applicable. Skin should be free of makeup and debris.

2

Apply to Target Areas

Dispense a few drops onto fingertips. Apply directly to forehead lines, between eyebrows (eleven lines), crow's feet, and smile lines.

3

Gently Pat In

Use gentle patting motions to help absorption. Avoid rubbing or pulling at the delicate eye area. Allow to absorb for 1-2 minutes.

4

Follow with Moisturizer

Layer with a moisturizer to seal in hydration. As a humectant, Argireline works best when followed by an occlusive product.

5

Use Twice Daily

Apply morning and evening for best results. Consistency is key โ€“ allow 4-8 weeks for visible improvement.

๐Ÿ‘ค Who Is It For?

โœ… Perfect for you if:

  • You have visible expression lines (forehead, crow's feet, frown lines)
  • You want a non-invasive alternative to Botox
  • You're looking for preventative anti-aging in your 20s-30s
  • You prefer clean, minimalist formulations
  • You have sensitive or acne-prone skin
  • You want to extend time between Botox appointments
  • You're on a budget but want effective anti-aging

โŒ Consider alternatives if:

  • You expect Botox-level results (this is gentler)
  • You have deep, static wrinkles (better for dynamic lines)
  • You're impatient โ€“ results take 4-8 weeks
  • You want an all-in-one anti-aging serum
  • You use a lot of direct acids or L-Ascorbic Acid Vitamin C
  • You're pregnant/breastfeeding (consult doctor first)

๐ŸŽฏ Skin Type Compatibility

Oily Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Lightweight, oil-free formula absorbs instantly without adding shine or greasiness. Won't clog pores.

Dry Skin โ˜…โ˜…โ˜…โ˜…โ˜† Good

Provides light hydration but will need a richer moisturizer on top. The humectant properties help attract moisture.

Combination Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Balanced formula works well across different face zones. Light enough for T-zone, hydrating for dry areas.

Sensitive Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Fragrance-free, alcohol-free, minimal ingredients. Low irritation potential. Patch test for very reactive skin.

Acne-Prone Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Non-comedogenic (0/5), oil-free, fungal acne safe. Won't trigger breakouts or feed acne-causing bacteria/yeast.

Mature Skin โ˜…โ˜…โ˜…โ˜…โ˜† Good

Best for dynamic wrinkles. For deep static wrinkles, combine with retinol (separate routines) or collagen-boosting treatments.

๐Ÿ“ˆ Results Timeline

Week 1-2

Initial Hydration & Smoothing

Skin feels more hydrated and slightly smoother. Temporary tightening sensation upon application. Product integrates into routine.

85% notice improved skin texture
Week 2-4

Early Wrinkle Softening

Fine lines begin to appear softer, especially around the eyes. Dynamic wrinkles look less pronounced when face is relaxed. Skin appears plumper.

65% see visible line reduction
Week 4-8

Noticeable Results

Clinical studies show 16-17% reduction in wrinkle depth. Expression lines on forehead and crow's feet visibly improved. Skin looks more relaxed and youthful.

64% report significant improvement
Month 3+

Cumulative Benefits

Continued use maintains results and may provide additional improvement. Preventative benefits for future wrinkle formation. Best results with consistent daily use.

Maintenance phase โ€“ ongoing use recommended

โญ Ratings by Platform

๐Ÿ’„ Sephora
โ˜…โ˜…โ˜…โ˜… 4.0
Rating
400+
Reviews
โš ๏ธ Main complaint: Results take time and are subtle compared to Botox expectations
๐Ÿ’… Ulta
โ˜…โ˜…โ˜…โ˜… 4.1
Rating
250+
Reviews
โš ๏ธ Main complaint: Small bottle size, requires consistent daily use
๐Ÿ›’ Amazon
โ˜…โ˜…โ˜…โ˜… 4.3
Rating
4,000+
Reviews
โš ๏ธ Main complaint: Concerns about product authenticity from third-party sellers
๐Ÿ  The Ordinary Website
โ˜…โ˜…โ˜…โ˜… 3.9
Rating
2,000+
Reviews
โš ๏ธ Main complaint: Some find the 6-month PAO limiting

โš–๏ธ Pros & Cons

โœ… Praised

  • Exceptional value โ€“ clinical peptide at drugstore price (~$10)
  • Lightweight, fast-absorbing, no residue
  • Suitable for all skin types including sensitive
  • Clean, minimal ingredient list (only 11 ingredients)
  • Fungal acne and acne-safe formula
  • Noticeable softening of expression lines with consistent use
  • Can extend Botox results between appointments
  • Fragrance-free, doesn't irritate eyes
  • Layers well under other products and makeup

โŒ Criticized

  • Results are gradual โ€“ not instant like Botox
  • Doesn't work as well on deep, static wrinkles
  • 6-month shelf life after opening is short
  • Small 30ml bottle can run out quickly with 2x daily use
  • Can pill under some products if not fully absorbed
  • Cannot use with direct acids or L-Ascorbic Acid
  • Some users see no visible difference
  • Requires patience and consistency

๐Ÿ’ฐ Budget-Friendly Alternatives (Dupes)

90% Match
Inzora Argi Matrix Serum (10% Argireline + 5% Matrixyl)
$8.99 Budget Pick

Combines Argireline with Matrixyl 3000 and Hyaluronic Acid in one formula. Slightly more complex but offers collagen-boosting benefits too.

85% Match
Cos De BAHA Peptide Serum with Matrixyl 3000 & Argireline
$14.80 Similar Price

Larger 60ml bottle with both peptides plus chamomile extract for soothing. More hydrating formula but less concentrated Argireline.

75% Match
ASTERWOOD Naturals Matrixyl 3000 + Argireline Serum
$19.95 Similar Price

Professional-grade peptide serum with organic Hyaluronic Acid. Larger 1oz size. Focus on both muscle relaxation and collagen synthesis.

70% Match
The Ordinary Multi-Peptide + HA Serum (Buffet)
$19.90 Premium Option

Contains Argireline plus Matrixyl and other peptides. Multi-target approach for overall anti-aging vs. focused expression line treatment.

๐Ÿ”„ Comparison with Competitors

The Ordinary Matrixyl 10% + HA

$16.20
Key Active 10% Matrixyl 3000
Size 30ml
Target Collagen/Firmness
Additional Benefits + Hyaluronic Acid
Price/ml $0.54/ml

The Ordinary Multi-Peptide + HA Serum

$19.90
Key Active Multiple Peptides
Size 30ml
Target Overall Anti-Aging
Additional Benefits Argireline + Matrixyl + More
Price/ml $0.66/ml

Peter Thomas Roth Peptide 21 Serum

$110.00
Key Active 21 Peptides + Neuropeptides
Size 30ml
Target Premium Anti-Aging
Additional Benefits Complex blend
Price/ml $3.67/ml

๐Ÿ“ฆ Storage & Shelf Life

๐Ÿ“…
Period After Opening (PAO)

6 months after opening. Mark the opening date on your bottle.

๐Ÿ 
Storage

Store in a cool, dry place away from direct sunlight. Refrigeration is optional but can extend freshness.

๐Ÿ“ฆ
Packaging

Glass dropper bottle with pipette applicator for precise dispensing and hygienic application.

โœˆ๏ธ
Travel Friendly

Yes, 30ml is under the 100ml TSA liquid limit. Pack upright to prevent leakage.

โ“ Frequently Asked Questions

There is limited data available. No studies have identified harmful effects from topical Argireline during pregnancy or breastfeeding. However, DECIEM has not conducted specific testing on pregnant or breastfeeding individuals. As a precaution, consult your healthcare provider or dermatologist before use. Many experts consider peptides generally safer than retinoids, but it's best to get professional guidance for your specific situation.

Yes! This product is completely fungal acne safe. It contains no fatty acids, oils, esters, polysorbates, or fermented ingredients that feed malassezia yeast. The water-based formula is free from all known triggers. Multiple sources including Skincarisma and SkinSort confirm its FA-safe status.

With retinol: Yes, you can use them together. Apply Argireline first as it's water-based, then retinol. Or use Argireline AM and retinol PM. With Vitamin C: Avoid using with L-Ascorbic Acid (direct vitamin C) in the same routine as the low pH can reduce peptide effectiveness. Stable vitamin C derivatives like Ascorbyl Tetraisopalmitate are fine. With AHA/BHA: Do not use in the same routine. Direct acids can degrade peptides. Use them at different times of day or on alternate days.

This serum is suitable for ALL skin types, including sensitive, oily, dry, combination, acne-prone, and mature skin. The lightweight, oil-free formula works especially well for oily and acne-prone skin. Those with dry skin should follow with a hydrating moisturizer. The fragrance-free, minimal formula makes it excellent for sensitive skin.

Initial hydration and smoothing: 1-2 weeks. Visible softening of fine lines: 2-4 weeks. Clinical studies show 16-17% reduction in wrinkle depth after 15-28 days of consistent use. Most users report noticeable results at the 4-8 week mark. Results accumulate with continued use. This is not an instant fix like Botox โ€“ patience and consistency are required.

Apply in the "Treat" step: After cleansing and toning, before heavier serums, oils, and moisturizers. As a water-based serum, it should go before any oil-based products. The order is: Cleanser โ†’ Toner โ†’ Argireline โ†’ Other serums โ†’ Moisturizer โ†’ Sunscreen (AM). Use morning and evening for best results.

No, this product has a comedogenic rating of 0/5. It is completely non-comedogenic. The oil-free, silicone-free formula contains no pore-clogging ingredients. It's safe for acne-prone skin and those who struggle with clogged pores or blackheads.

The Period After Opening (PAO) is 6 months. Once opened, peptides can degrade over time, so it's important to use the product within this timeframe. With twice-daily use on target areas, the 30ml bottle typically lasts 2-4 months, well within the PAO. Store properly in a cool, dry place away from sunlight to maximize shelf life.

Yes, you can apply it all over your face and neck if desired, though it's designed primarily for expression line areas (forehead, between brows, crow's feet, smile lines). Many users find it hydrating for the entire face. The gentle formula is safe for widespread use.

While Argireline works through a similar mechanism to Botox (inhibiting muscle contractions), it's important to have realistic expectations. It's NOT as powerful as injectable Botox. Clinical studies show it can reduce wrinkle depth by about 17% โ€“ impressive for a topical, but nowhere near Botox results. Think of it as a gentle, non-invasive alternative for fine lines, or as a complement to extend time between Botox appointments. It's best for prevention and mild improvement rather than dramatic transformation.

โ˜…โ˜…โ˜…โ˜…โ˜†
4.0 out of 5

Verdict: The Ordinary Argireline Solution 10% delivers exceptional value as a targeted treatment for expression lines. At under $10 for a clinical-grade peptide serum, it's hard to beat. While it won't replace Botox, consistent users report visibly softer forehead lines and crow's feet within 4-8 weeks. The clean, minimalist formula suits all skin types including sensitive and acne-prone skin. Best for those seeking preventative anti-aging or gentle wrinkle softening. Requires patience and consistency โ€“ this is a marathon, not a sprint. Ideal as part of a comprehensive anti-aging routine alongside sunscreen and retinol (used separately).

Product Information

Shipping & Returns

Description

A lightweight, water-based peptide serum featuring 10% Argireline (Acetyl Hexapeptide-8) that targets expression lines around the forehead, eyes, and smile area. Often called "Botox in a bottle," this non-injective formula helps relax the appearance of dynamic wrinkles for smoother, more youthful-looking skin.

๐Ÿ‡จ๐Ÿ‡ฆ Clean Beauty ยท Made in Canada
โœ” Vegan โœ” Cruelty-Free โœ” Fragrance-Free โœ” Oil-Free โœ” Silicone-Free โœ” Alcohol-Free โœ” Gluten-Free โœ” Fungal Acne Safe
Pregnancy Safe
Caution โš ๏ธ
Fungal Acne Safe
Yes โœ”
Comedogenic Rating
0/5
๐Ÿ’ง
Size
30ml / 1 fl oz
๐Ÿงช
Active
10% Argireline
๐Ÿ“Š
pH Level
~6.0
๐ŸŽฏ
Target
Expression Lines
โฐ
Use
AM & PM

โœจ Texture & Feel

๐Ÿ’ง
Consistency
Watery Serum
๐Ÿ‘ƒ
Scent
Fragrance-Free
โฑ๏ธ
Absorption
Instant
๐ŸŽฏ
Finish
Natural/Hydrated
๐Ÿ’‰

Non-Injective Anti-Aging

Mimics the muscle-relaxing effects of Botox topically without needles, helping to soften dynamic expression lines.

๐ŸŽฏ

Targeted Treatment

Specifically formulated for forehead lines, "eleven" frown lines, crow's feet, and smile lines.

๐Ÿ’ง

Water-Based Formula

High water content maximizes Argireline efficacy. Free from oils, esters, and silicones for better absorption.

๐Ÿงด

Minimalist Formulation

Only 11 ingredients focused on delivering the active without unnecessary fillers or irritants.

๐Ÿ›ก๏ธ Safety & Compatibility

โš ๏ธ
Pregnancy & Breastfeeding

Limited data available. No studies have identified harmful effects, but consult your healthcare provider before use as a precaution.

โœ…
Fungal Acne (Malassezia) Safe

Contains no fatty acids, oils, esters, polysorbates, or fermented ingredients that feed malassezia yeast.

โœ…
Non-Comedogenic

Rating 0/5. Oil-free and silicone-free formula will not clog pores or cause breakouts.

โœ…
Sensitive Skin Friendly

Fragrance-free, alcohol-free formula with low irritation potential. Patch test recommended for very reactive skin.

โš ๏ธ
Avoid with Direct Acids & Vitamin C

Do not use in the same routine as AHAs, BHAs, L-Ascorbic Acid, or Ethylated Vitamin C. Low pH can reduce peptide efficacy.

๐Ÿ’ก
Patch Test Recommended

Apply a small amount to inner forearm and wait 24 hours before full facial application.

๐Ÿ”ฌ Ingredient Breakdown

๐Ÿงฌ Argireline (Acetyl Hexapeptide-8) 10% Proven

A synthetic hexapeptide that works by inhibiting the SNARE complex, reducing neurotransmitter release that causes muscle contractions. This relaxes facial muscles and reduces the appearance of expression lines.

  • Clinical Study: 10% Argireline reduced wrinkle depth by 17% after 15 days of use around the eyes.
  • Research: 5% concentration showed 16.26% decrease in wrinkle depth after 28 days.
  • Mechanism: Mimics SNAP-25 protein fragment, similar to botulinum toxin's target but applied topically.
  • NIH Study: Can extend Botox results when used regularly between treatments.
โš ๏ธ
Works best with consistent twice-daily use. Results are gradual and not as dramatic as injectable Botox.

๐Ÿ’ง Propanediol Solvent Supporting

A naturally-derived solvent (from corn) that enhances the absorption and penetration of Argireline into the skin. Also provides light hydration and improves product texture.

  • Function: Enhances delivery of active ingredients into skin
  • Source: Plant-derived, sustainable alternative to propylene glycol
  • Benefit: Moisturizing properties without heaviness

๐Ÿ”— Dimethyl Isosorbide Penetration Enhancer Supporting

A penetration enhancer that helps active ingredients reach deeper skin layers where they can be most effective. Improves the bioavailability of Argireline.

  • Function: Boosts delivery of peptides through the skin barrier
  • Safety: Well-tolerated, non-irritating carrier ingredient

11 ingredients

Aqua (Water), Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin

FREE FROM: Parabens, Sulfates (SLS/SLES), Mineral Oil, Silicones, Oils, Fragrance, Alcohol, Gluten, Animal-derived Ingredients, Formaldehyde, Phthalates, Oxybenzone, Coal Tar, Hydroquinone, Triclosan

๐Ÿ”„ Where It Fits in Your Routine

1
Cleanser
2
Toner
3
Argireline Serum
4
Hydrating Serum
5
Moisturizer
6
Sunscreen (AM)

Apply in the "Treat" stage after cleansing/toning and before heavier treatments. Water-based serums go before oil-based products.

๐Ÿ“ How to Use

1

Cleanse & Prep

Start with clean, dry skin. Use after toner if applicable. Skin should be free of makeup and debris.

2

Apply to Target Areas

Dispense a few drops onto fingertips. Apply directly to forehead lines, between eyebrows (eleven lines), crow's feet, and smile lines.

3

Gently Pat In

Use gentle patting motions to help absorption. Avoid rubbing or pulling at the delicate eye area. Allow to absorb for 1-2 minutes.

4

Follow with Moisturizer

Layer with a moisturizer to seal in hydration. As a humectant, Argireline works best when followed by an occlusive product.

5

Use Twice Daily

Apply morning and evening for best results. Consistency is key โ€“ allow 4-8 weeks for visible improvement.

๐Ÿ‘ค Who Is It For?

โœ… Perfect for you if:

  • You have visible expression lines (forehead, crow's feet, frown lines)
  • You want a non-invasive alternative to Botox
  • You're looking for preventative anti-aging in your 20s-30s
  • You prefer clean, minimalist formulations
  • You have sensitive or acne-prone skin
  • You want to extend time between Botox appointments
  • You're on a budget but want effective anti-aging

โŒ Consider alternatives if:

  • You expect Botox-level results (this is gentler)
  • You have deep, static wrinkles (better for dynamic lines)
  • You're impatient โ€“ results take 4-8 weeks
  • You want an all-in-one anti-aging serum
  • You use a lot of direct acids or L-Ascorbic Acid Vitamin C
  • You're pregnant/breastfeeding (consult doctor first)

๐ŸŽฏ Skin Type Compatibility

Oily Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Lightweight, oil-free formula absorbs instantly without adding shine or greasiness. Won't clog pores.

Dry Skin โ˜…โ˜…โ˜…โ˜…โ˜† Good

Provides light hydration but will need a richer moisturizer on top. The humectant properties help attract moisture.

Combination Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Balanced formula works well across different face zones. Light enough for T-zone, hydrating for dry areas.

Sensitive Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Fragrance-free, alcohol-free, minimal ingredients. Low irritation potential. Patch test for very reactive skin.

Acne-Prone Skin โ˜…โ˜…โ˜…โ˜…โ˜… Excellent

Non-comedogenic (0/5), oil-free, fungal acne safe. Won't trigger breakouts or feed acne-causing bacteria/yeast.

Mature Skin โ˜…โ˜…โ˜…โ˜…โ˜† Good

Best for dynamic wrinkles. For deep static wrinkles, combine with retinol (separate routines) or collagen-boosting treatments.

๐Ÿ“ˆ Results Timeline

Week 1-2

Initial Hydration & Smoothing

Skin feels more hydrated and slightly smoother. Temporary tightening sensation upon application. Product integrates into routine.

85% notice improved skin texture
Week 2-4

Early Wrinkle Softening

Fine lines begin to appear softer, especially around the eyes. Dynamic wrinkles look less pronounced when face is relaxed. Skin appears plumper.

65% see visible line reduction
Week 4-8

Noticeable Results

Clinical studies show 16-17% reduction in wrinkle depth. Expression lines on forehead and crow's feet visibly improved. Skin looks more relaxed and youthful.

64% report significant improvement
Month 3+

Cumulative Benefits

Continued use maintains results and may provide additional improvement. Preventative benefits for future wrinkle formation. Best results with consistent daily use.

Maintenance phase โ€“ ongoing use recommended

โญ Ratings by Platform

๐Ÿ’„ Sephora
โ˜…โ˜…โ˜…โ˜… 4.0
Rating
400+
Reviews
โš ๏ธ Main complaint: Results take time and are subtle compared to Botox expectations
๐Ÿ’… Ulta
โ˜…โ˜…โ˜…โ˜… 4.1
Rating
250+
Reviews
โš ๏ธ Main complaint: Small bottle size, requires consistent daily use
๐Ÿ›’ Amazon
โ˜…โ˜…โ˜…โ˜… 4.3
Rating
4,000+
Reviews
โš ๏ธ Main complaint: Concerns about product authenticity from third-party sellers
๐Ÿ  The Ordinary Website
โ˜…โ˜…โ˜…โ˜… 3.9
Rating
2,000+
Reviews
โš ๏ธ Main complaint: Some find the 6-month PAO limiting

โš–๏ธ Pros & Cons

โœ… Praised

  • Exceptional value โ€“ clinical peptide at drugstore price (~$10)
  • Lightweight, fast-absorbing, no residue
  • Suitable for all skin types including sensitive
  • Clean, minimal ingredient list (only 11 ingredients)
  • Fungal acne and acne-safe formula
  • Noticeable softening of expression lines with consistent use
  • Can extend Botox results between appointments
  • Fragrance-free, doesn't irritate eyes
  • Layers well under other products and makeup

โŒ Criticized

  • Results are gradual โ€“ not instant like Botox
  • Doesn't work as well on deep, static wrinkles
  • 6-month shelf life after opening is short
  • Small 30ml bottle can run out quickly with 2x daily use
  • Can pill under some products if not fully absorbed
  • Cannot use with direct acids or L-Ascorbic Acid
  • Some users see no visible difference
  • Requires patience and consistency

๐Ÿ’ฐ Budget-Friendly Alternatives (Dupes)

90% Match
Inzora Argi Matrix Serum (10% Argireline + 5% Matrixyl)
$8.99 Budget Pick

Combines Argireline with Matrixyl 3000 and Hyaluronic Acid in one formula. Slightly more complex but offers collagen-boosting benefits too.

85% Match
Cos De BAHA Peptide Serum with Matrixyl 3000 & Argireline
$14.80 Similar Price

Larger 60ml bottle with both peptides plus chamomile extract for soothing. More hydrating formula but less concentrated Argireline.

75% Match
ASTERWOOD Naturals Matrixyl 3000 + Argireline Serum
$19.95 Similar Price

Professional-grade peptide serum with organic Hyaluronic Acid. Larger 1oz size. Focus on both muscle relaxation and collagen synthesis.

70% Match
The Ordinary Multi-Peptide + HA Serum (Buffet)
$19.90 Premium Option

Contains Argireline plus Matrixyl and other peptides. Multi-target approach for overall anti-aging vs. focused expression line treatment.

๐Ÿ”„ Comparison with Competitors

The Ordinary Matrixyl 10% + HA

$16.20
Key Active 10% Matrixyl 3000
Size 30ml
Target Collagen/Firmness
Additional Benefits + Hyaluronic Acid
Price/ml $0.54/ml

The Ordinary Multi-Peptide + HA Serum

$19.90
Key Active Multiple Peptides
Size 30ml
Target Overall Anti-Aging
Additional Benefits Argireline + Matrixyl + More
Price/ml $0.66/ml

Peter Thomas Roth Peptide 21 Serum

$110.00
Key Active 21 Peptides + Neuropeptides
Size 30ml
Target Premium Anti-Aging
Additional Benefits Complex blend
Price/ml $3.67/ml

๐Ÿ“ฆ Storage & Shelf Life

๐Ÿ“…
Period After Opening (PAO)

6 months after opening. Mark the opening date on your bottle.

๐Ÿ 
Storage

Store in a cool, dry place away from direct sunlight. Refrigeration is optional but can extend freshness.

๐Ÿ“ฆ
Packaging

Glass dropper bottle with pipette applicator for precise dispensing and hygienic application.

โœˆ๏ธ
Travel Friendly

Yes, 30ml is under the 100ml TSA liquid limit. Pack upright to prevent leakage.

โ“ Frequently Asked Questions

There is limited data available. No studies have identified harmful effects from topical Argireline during pregnancy or breastfeeding. However, DECIEM has not conducted specific testing on pregnant or breastfeeding individuals. As a precaution, consult your healthcare provider or dermatologist before use. Many experts consider peptides generally safer than retinoids, but it's best to get professional guidance for your specific situation.

Yes! This product is completely fungal acne safe. It contains no fatty acids, oils, esters, polysorbates, or fermented ingredients that feed malassezia yeast. The water-based formula is free from all known triggers. Multiple sources including Skincarisma and SkinSort confirm its FA-safe status.

With retinol: Yes, you can use them together. Apply Argireline first as it's water-based, then retinol. Or use Argireline AM and retinol PM. With Vitamin C: Avoid using with L-Ascorbic Acid (direct vitamin C) in the same routine as the low pH can reduce peptide effectiveness. Stable vitamin C derivatives like Ascorbyl Tetraisopalmitate are fine. With AHA/BHA: Do not use in the same routine. Direct acids can degrade peptides. Use them at different times of day or on alternate days.

This serum is suitable for ALL skin types, including sensitive, oily, dry, combination, acne-prone, and mature skin. The lightweight, oil-free formula works especially well for oily and acne-prone skin. Those with dry skin should follow with a hydrating moisturizer. The fragrance-free, minimal formula makes it excellent for sensitive skin.

Initial hydration and smoothing: 1-2 weeks. Visible softening of fine lines: 2-4 weeks. Clinical studies show 16-17% reduction in wrinkle depth after 15-28 days of consistent use. Most users report noticeable results at the 4-8 week mark. Results accumulate with continued use. This is not an instant fix like Botox โ€“ patience and consistency are required.

Apply in the "Treat" step: After cleansing and toning, before heavier serums, oils, and moisturizers. As a water-based serum, it should go before any oil-based products. The order is: Cleanser โ†’ Toner โ†’ Argireline โ†’ Other serums โ†’ Moisturizer โ†’ Sunscreen (AM). Use morning and evening for best results.

No, this product has a comedogenic rating of 0/5. It is completely non-comedogenic. The oil-free, silicone-free formula contains no pore-clogging ingredients. It's safe for acne-prone skin and those who struggle with clogged pores or blackheads.

The Period After Opening (PAO) is 6 months. Once opened, peptides can degrade over time, so it's important to use the product within this timeframe. With twice-daily use on target areas, the 30ml bottle typically lasts 2-4 months, well within the PAO. Store properly in a cool, dry place away from sunlight to maximize shelf life.

Yes, you can apply it all over your face and neck if desired, though it's designed primarily for expression line areas (forehead, between brows, crow's feet, smile lines). Many users find it hydrating for the entire face. The gentle formula is safe for widespread use.

While Argireline works through a similar mechanism to Botox (inhibiting muscle contractions), it's important to have realistic expectations. It's NOT as powerful as injectable Botox. Clinical studies show it can reduce wrinkle depth by about 17% โ€“ impressive for a topical, but nowhere near Botox results. Think of it as a gentle, non-invasive alternative for fine lines, or as a complement to extend time between Botox appointments. It's best for prevention and mild improvement rather than dramatic transformation.

โ˜…โ˜…โ˜…โ˜…โ˜†
4.0 out of 5

Verdict: The Ordinary Argireline Solution 10% delivers exceptional value as a targeted treatment for expression lines. At under $10 for a clinical-grade peptide serum, it's hard to beat. While it won't replace Botox, consistent users report visibly softer forehead lines and crow's feet within 4-8 weeks. The clean, minimalist formula suits all skin types including sensitive and acne-prone skin. Best for those seeking preventative anti-aging or gentle wrinkle softening. Requires patience and consistency โ€“ this is a marathon, not a sprint. Ideal as part of a comprehensive anti-aging routine alongside sunscreen and retinol (used separately).